![]() The other option is that one cell type is generated in a stereotypic position to then recruit a second cell type to fulfil a new role in situ. This typically happens during the formation of gonads in vertebrates, where germ cells follow a directional migration towards the somatic cells that will form their stem cell niche and eventually the gonad ( Doitsidou et al., 2002 Santos and Lehmann, 2004). One option is that they originate from cells that form in remote areas and migrate to a common pre-defined location. There are two alternative scenarios on how cells from different lineages successfully come together during embryogenesis to assemble composite organs. Even though a broad range of molecular details have been uncovered, those did not contribute to revealing how cells from different embryonic origins end up together in the same functional unit. This approach resulted in a deeper understanding of the molecular networks that control organogenesis in both vertebrates and invertebrates ( Gilbert, 2014). The last decades have witnessed huge efforts focused on identifying molecules necessary for organ formation in a wide range of organisms. We hypothesise that induction of surrounding tissues plays a major role during the establishment of vertebrate stem cell niches.Īnimal organs are composed of diverse cell types, which in most cases derive from different embryonic origins. Our results demonstrate that the neural lineage is necessary and sufficient to generate nBCs highlighting self-organisation principles at the level of the entire embryo. Clonal analysis and 4D imaging revealed a hierarchical organisation with instructing and responding roles: an inner, neural lineage induces the formation of an outer, border cell lineage (nBC) from the skin epithelium. ![]() Here we show that neuromasts of the posterior lateral line in medaka are composed of two independent life-long lineages with different embryonic origins. ![]() Little is known, however, on how these different stem cells locate to forming organs during development. Typically, stem cells of independent lineages work coordinately within mature organs to ensure proper ratios of cell types. Most organs rely on stem cells to maintain homeostasis during post-embryonic life. ![]()
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